An eye for science

Medicine@Yale, 2006 - Sept Oct

Features
News
Grants and contracts awarded to Yale School of Medicine
Protein sleuths’ lab works around the clock
Throwing new light on cellular networks
Yale launches new stem cell research program
When lifting weights, keep your heart in mind
How cold sore viruses play hide-and-seek
An eye for science
An early start on the road to reason
Nicotine’s addictive grip on the brain
People

widefield fluorescence micrograph

After immunization, large numbers of B lymphocytes that are specific for the foreign compound form an aggregate of dividing cells known as a germinal center, seen here in a widefield fluorescence micrograph made by Associate Research Scientist Ann M. Haberman, Ph.D., in the laboratory of Mark J. Shlomchik, M.D., Ph.D., professor of laboratory medicine and immunobiology. As the germinal center expands, non-responding B cells (green) are displaced by responding B cells (blue), forming a corona around the germinal center. Contact with the fine extensions of follicular dendritic cells (red) encourages long-term survival and differentiation of germinal center B cells.

Confocal micrograph of a tick

Confocal micrograph of a tick from the family Ixodes, the vector for Lyme disease. Ruth R. Montgomery, Ph.D., senior research scientist in the Department of Internal Medicine’s Section of Rheumatology, and Utpal Pal, Ph.D., now an assistant professor at the Virginia-Maryland Regional College of Veterinary Medicine, imaged living ticks 24 hours after injecting them with fluorescent dyes to label surface structures and cells in the midgut.

Scanning electron micrograph

Scanning electron micrograph by Daniel Biemesderfer, Ph.D., assistant professor of medicine, of a glomerulus in the kidney of the two-toed amphiuma (Amphiuma means), a salamander found in the southeastern United States. Glomeruli are found in the nephron, the basic structural and functional unit of all vertebrate kidneys. They are composed of capillaries and an epithelium that filters the blood. Here, epithelial cells (round and oval structures) are seen sending out extensions to surround the capillaries (tubular structures) beneath.

A section of rectal mucosa tissue from a macaque monkey stained with fluorescent antibodies

A section of rectal mucosa tissue from a macaque monkey stained with fluorescent antibodies to DC-SIGN (green) and CCR5 (red) and imaged with confocal microscopy by Akiko Iwasaki, Ph.D., associate professor of immunobiology. DC-sign binds to the human immunodeficiency virus (HIV-1) and CCR5 is a co-receptor for HIV-1. Cell nuclei are seen in blue.

The TAC Gallery, located in the School of Medicine’s Anlyan Center, showcases scientific images created in medical school laboratories. Co-directed by Lorraine F. Roseman, operations manager and customer advocate in the medical school’s Office of Facilities, and Terry Dagradi, image specialist in the ITS-Med Media Group, the gallery was made possible by the Facilities Operations group.

How cold sore viruses play hide-and-seek

An early start on the road to reason