Medicine@Yale Magazine

Medicine@Yale.

June/July 2005   Volume 1 Issue 1

Inside this issue

Cover stories

The big questions

New Kavli center for neuroscience research will untangle mysteries of the human brain

Molecular gamble

Yale physiologist elected to National Academy of Sciences

Trailblazer

Magazine innovator celebrates 101 years with gifts for his medical school “family”

People

Lifelines: Expert on gene-swapping joined molecular biology at its very beginnings

For new deputy dean, focus is on top-notch care, service to patients

Kidney researchers celebrate a banner year

Unconventional physician-filmmaker receives “genius” grant

New HHMI investigator says appointment liberates his science

Awards & honors

Science

Analysis of genome reveals clues to macular degeneration

Vaccinating wildlife suggests a new strategy in continuing battle against Lyme disease

Advances:  Salmonella “syringe” ready for its close-up | Possible cancer inhibitor found in worm study

Health

A heart is repaired, the patient grows up: Program helps growing number of adult survivors of congenital disease

More integrated care for cancer patients, collaboration of scientists and clinicians are goals of proposed new YNHH building

Advances: New test easier for patients to swallow. | Study finds payoff in wider HIV testing

Partnerships

Pfizer and Yale join forces for research and education

A long, fruitful collaboration: Bristol-Myers Squibb and Yale

Drive to cure blindness hits $5 million

Class of 1954 makes a lasting impact with scholarship gift

Grants and contracts

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January/February 2005

Grants and contracts awarded to Yale School of Medicine

Federal

  • Karen Anderson, NIH, A Novel Approach for Studying Transient Enzyme Intermediates, 4 years, $1,219,062
  • Susan Baserga, NIH, Assembly, Localization and Function of the U3 snRNP, 4 years, $1,433,671
  • Kevin Behar, NIH, NMR Studies of Brain Energetics and Hypoglycemia In Vivo, 4 years, $1,438,800
  • Walter Boron, Office of Naval Research, Gas Transport Through Channels, 3 years, $189,683
  • Peter Bowers, NIH, Identification of a Gene Causing Aortic Stenosis, 2 years, $449,625
  • Lawrence Brass, NIH, Stroke Hospitalization in the Elderly with Medicare FFS (SHEF) Study, 4 years, $1,244,091
  • Cecilia Canessa, NIH, Regulation of ENaC by SGK1, 5 years, $1,798,500
  • Michael Cappello, NIH, The Role of MIF in Hookworm Infection and Disease, 5 years, $2,027,875
Hookworm.

Michael Cappello and colleagues are investigating the molecular pathogenesis of hookworm infection, which retards physical and mental development in as many as 1 billion people around the world. This photomicrograph shows the worm's mouth at the lower right.


  • James Duncan, NIH, Integrated Function/Structure Image Analysis in Autism, 5 years, $1,835,724
  • Cynthia Epperson, NIH, Neuroactive Steroids, GABA and Glutamate, in PMDD, 5 years, $614,117
  • Mark Hochstrasser, NIH, Degradation of Short-Lived Regulatory Proteins in Yeast, 4 years, $1,422,452
  • Stuart Katz, NIH, Studies on Genetics in Heart Failure, 5 years, $803,994
  • Kenneth Kidd, NIH, ADH and ALDH2 Genes in Tanzanian Population, 3 years, $102,500
  • Walther Mothes, NIH, Retroviral Egress via Multivesicular Bodies, 2 years, $489,788
  • Chirag Parikh, NIH, Renal Failure in Non-Myeloablative Stem Cell Transplant, 3.5 years, $142,830
  • Archibald Perkins, NIH, Leukemic Transformation by the AML1/ MDS1/EVI1 Protein, 5 years, $1,507,211
  • Robert Schultz, NIH, The Fusiform Gyrus and Amygdala in the Pathobiology of Autism, 5 years, $1,635,000
  • Frederick Sigworth, NIH, Fluctuations in Ionic Current through Membrane Channels, 4 years, $2,424,419
  • Elisabetta Ullu, NIH, RNA Metabolism in Trypanosomes, 5 years, $3,559,787
  • Anthony Van den Pol, NIH, Response Properties of Hypothalamic MCH Neurons, 5 years, $1,701,420
  • Shu-Ming Wang, NIH, Acupuncture and Low Back Pain During Pregnancy, 3 years, $654,000

Non-Federal

  • Thomas Biederer, March of Dimes, Analysis of a Molecular Link Between Synapse Formation and Neurodevelopmental Disorders, 1 year, $150,000
  • Daniel Biemesderfer, American Society of Nephrology, Megalin Function in Normal and Diseased Kidney, 1 year, $100,000
  • Jonathan Bogan, American Diabetes Association, Regulation of Glucose Transporter Trafficking, 1 year, $100,000
  • Mary Bogucki, Sekos Inc., SCBA Oximetry for Fire-Fighter Physiological Monitoring—Phase II, 1 year, 8 months, $231,909
  • Yiqiang Cai, The PKD Foundation, Study of Polycystin-1 Ciliary Localization/Trafficking and the Underlying Molecular Determinants, 1 year, $65,000
  • Michael Caplan, Cystic Fibrosis Foundation, The Effects of Curcumin Treatment on the Function of Gamma F508 CFTR, 1 year, $108,000
  • Thomas Carpenter, The Gerber Foundation, Biomarkers of Dietary Calcium Insufficiency in Inner-City Infants, 3 years, $844,432
  • Joseph Craft, The Arthritis Foundation, CNS Lupus: Mechanistic Dissection, 2 years, $200,000
  • Richard Edelson, American Cancer Society, American Cancer Society Institutional Research Grant, 3 years, $420,000
  • Ramsay Fuleihan, Bayer Healthcare, Molecular Pathogenesis of Antibody Deficiency Syndrome, 1 year, $74,760
  • Satish Ghatpande, American Heart Association, Elucidation of Retinoid Signaling Pathway for Cardiac Morphogenesis, 4 years, $65,000
  • Thomas Gill, University of Florida, Exercise to Prevent Disability—Pilot Study, 7 months, $29,853
  • Walter Gilliam, The William Caspar Graustein Memorial Fund, Preschool in Connecticut: Linking Community Data to a National Pre-K Context, 1 year, $38,220
  • Robert Kerns, The Patrick and Catherine Weldon Donaghue Medical Research Foundation, CBT for Painful Diabetic Neuropathy, 3 years, $223,795
  • Dori Laub, The International Psychoanalytical Association, Video Testimony Study of Chronically Hospitalized Holocaust Survivors in Israel, 1 year, $8,000
  • Chun Geun Lee, American Thoracic Society, Genetic Factors Controlling TGF-beta 1 in the Pathogenesis of COPD, 2 years, $50,000
  • Graeme Mason, Pfizer, Development of Non-Occipital, Multi-Volume GABA MRS at 4 Tesla—An Investigator-Initiated Proposal, 2 years, $472,095
  • Daniel Mathalon, Alcoholic Beverage Medical Research Foundation, Automatic Processing of Alcohol Cues in Chronic Alcoholism: ERP and fMRI Data, 2 years, $100,000
  • Sherry McKee, Alcoholic Beverage Medical Research Foundation, Effect of Alcohol on Reactivity to Tobacco in Experimental Smokers, 2 years, $100,000
  • Linda Niccolai, The Patrick and Catherine Weldon Donaghue Medical Research Foundation, Risk in Partnerships for Repeat Sexually Transmitted Infection, 3 years, $240,000
  • Timothy Quan, Scleroderma Foundation, The Role of Fibrocytes in Nephrogenic Fibrosing Dermopathy, 3 years, $100,000
  • Joseph Schlessinger, Ludwig Institute for Cancer Research, Intracellular Signaling Pathway for Cell Signaling in Cancer and Other Diseases, 1 year, $375,000
  • Nenad Sestan,Whitehall Foundation, Molecular Control of Pyramidal Cell Identity and Connectivity, 3 years, $225,000
  • Hosanna Soler, American Cancer Society, Psychosocial Factors, Race and Cancer Survival, 5 years, $129,400
  • Julie Ann Sosa, Association for Academic Surgery, Effects of Parathyroidectomy on Neurocognitive Function in Primary Hyperparathyroidism, 1 year, $35,000
  • Stephen Strittmatter, Christopher Reeve Paralysis Foundation, Axonal Regeneration Pharmaceuticals for Recovery from Spinal Cord Injury, 3 years, $805,477
  • Mary Tinetti, The John A. Hartford Foundation, Yale University Center of Excellence in Aging, 3 years, $300,000
  • Li Wen, The Seaver Institute, Dendritic Cell Therapy for Autoimmune Disease, 1 year, $120,000
  • James Yue, Abbott Spine, ISD in a Caprine Model, 1 year, $240,242
  • Hongyu Zhao, Bioinformatics Support for the Analysis of Panomic Data in Order to Identify Potential Biomarkers and Mechanisms of Drug-Induced Vascular Injury, 1 year, $270,000
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