Inside this issue
YALE PROJECTS FOR GLOBAL HEALTH RECEIVE MAJOR FUNDING
A new front in the war on antibiotic-resistant bacteria
From the pages of Cell to The Tonight Show’s stage
Applera Corp. boosts education
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Grants and contracts awarded to Yale School of Medicine, March/April 2005
Federal
- George Aghajanian, NIH, Psychotogenic Drug Action on
Chemically Defined Neurons, 4 years, $931,200
- Thomas Biederer, NIH, Mechanisms of Syncam-Induced
Synapse Formation, 5 years, $1,445,391
- Jonathan Bogan, NIH, Proteomic Characterization of
Insulin Signaling Targets, 2 years, $327,000
- Richard Bungiro, NIH, Mucosal Immune Responses in Hookworm
Infection, 2 years, $163,500
- Edward Chu, NIH, Molecular Regulation of Translational
Regulation, 4 years, $886,720
- Lauren Cohn, NIH, T Cell Control of Airway Mucus Production,
5 years, $2,043,750
- Ralph DiLeone, NIH, Investigating the Role of Leptin
Signaling in the Ventral Tegmental Area, 2 years, $400,125
- Gail D’Onofrio, NIH, Enhancing Emergency Room
Physician-Performed Alcohol Interventions in the Emergency Department,
5 years, $3,461,863
- Durland Fish, Department of Agriculture, Eco-Epidemiology
of Emerging Arthropod-Borne Pathogens in the Northeast, 1 year, $300,781
- Gerald Friedland, NIH, New England Program for AIDS
Clinical Trial—PROACT, 1 year, $802,492
- Guadalupe Garcia-Tsao, NIH, Cirrhosis and Its Complications,
5 years, $775,659
- Peter Glazer, NIH, Cisplatin Damage Response and Cell-to-Cell
Communication, 5 years, $1,446,633
- Ruth Halaban, NIH, Epigenetic Chromatin Changes as
Melanoma Markers, 2 years, $281,220
- Hatim Hassan, NIH, Mechanisms of Regulation of Anion
Exchanger SLC26A6, 5 years, $710,100
- Michael E. Hodsdon, NIH, Structural Basis of Prolactin
Receptor Recognition, 5 years, $1,465,139
- Mark Horowitz, NIH, Regulation of Bone Remodeling by
Megakaryocytes, 5 years, $1,798,500
- Themis Kyriakides, NIH, MCP-1 and Attenuation of the
Foreign Body Response, 5 years, $1,524,640
- Linda Mayes, NIH, Neurocognitive Development in Children
Living in Poverty, 5 years, $2,529,478
- David McCormick, NIH, Neurotransmitter Actions in Neocortex
and Thalamus, 4 years, $1,660,477
- Laura Ment, NIH, Multicenter Randomized Indomethacin
Intraventricular Hemorrhage Prevention Trial, 5 years, $6,965,242
- Pramod Mistry, NIH, Patient-Oriented Research in Inherited
Metabolic Liver Diseases, 5 years, $738,291
- Michael Nathanson, NIH, Ca2+ Waves
in Hepatocytes: Mechanisms and Effects, 5 years, $486,127
- Paul Noble, NIH, Regulation of Pulmonary Fibrosis by
CXCR3, 4 years, $1,635,000
- Lynne Regan, NIH, High-Throughput Assays for Inhibitors
of Protein-Protein Interactions, 3 years, $975,058
- Jennifer Ruger, NIH, Economic Evaluation of Addiction
Services, 3 years, $445,818
- Raymond Russell, NIH, Function and Regulation of Cardiac
Uncoupling Proteins, 4 years, $1,308,000
- Joseph Santos-Sacchi, NIH, Membrane Properties of Cells
Comprising the Outer Hair Cell System, 5 years, $2,388,206
- Gerald Shadel, Department of the Army, Nuclear-Mitochondrial
Signals That Control Oxidative Stress Resistance and Longevity, 3 years,
$294,034
- Albert Shaw, NIH, Top3 Homologues in Lymphocyte Genome
Stability and Aging, 5 years, $355,175
- Dieter Soll, NIH, Studies on Transfer RNA, 4 years,
$5,345,449
- Stefan Somlo, NIH, Genetics of Autosomal Dominant Polycystic
Liver Disease, 5 years, $2,401,172
- Carlos Stocco, NIH, Regulation of Estradiol Production
by Prostaglandin F2alpha, 2 years, $163,500
- Stephen Strittmatter, NIH, Molecular Determinants of
Axonal Regeneration, 4 years, $1,512,376
- Peter Takizawa, NIH, Mechanism of mRNA Transport by
Myo4p, 5 years, $1,379,288
- Sandra Wolin, NIH, RNA Quality Control and Environmental
Stress, 4 years, $1,316,769
- Lawrence Young, NIH, Regulation of Glucose Transport
in the Ischemic Heart, 4 years, $1,471,500
In NIH-funded research reported in Cell in May, Sandra Wolin and Karin Reinisch of the Department of Cell Biology determined how the Ro protein, a major target of the immune system in patients with autoimmune diseases such as lupus, binds to RNA. In normal cell metabolism, Ro is thought to function in quality control of noncoding RNAs, ensuring that misfolded and defective RNAs are degraded. These misfolded RNAs bind both on the outer surface of Ro (green and purple strands) and in a hole in the protein (blue strand).
Non-Federal
- Richard Bucala, Alliance for Lupus Research, Macrophage Migration Inhibitory Factor Inhibition in Systemic Lupus Erythematosus, 1 year, $250,000
- Ronald Duman, Organon Inc., Influence of Organon #2448 and Organon #26576 on Neurogenesis in the Adult Hippocampus, 1 year, $221,160
- Marie Egan, Cystic Fibrosis Foundation, The Effects of Curcumin Treatment on the Function of Delta F508 Cystic Fibrosis Transmembrane Conductance Regulator, 1 year, $108,000
- Alan Garen, Sidney Kimmel Cancer Center, Targeting Vessels in Tumors, 5 years, $168,067
- Susan Kaech, Edward Mallinckrodt Jr. Foundation, Identifying the Genes That Regulate Formation of Memory CD8 T Cell Precursors, 3 years, $50,000
- Elias Lolis, Robert Leet and Clara Guthrie Patterson Trust, Identification of the Allosteric Sites of CXCR4, 1 year, $75,000
- Stephen Malawista, G. Harold and Leila Y. Mathers Charitable Foundation, Leukocytes and Inflammation, 1 year, $110,000
- David Morris, Robert Leet and Clara Guthrie Patterson Trust, Pathogenesis of Fibrotic Lung Disease, 1 year, $75,000
- David Rimm, Breast Cancer Alliance Inc., Spectral-Spatial Imaging to Detect Premalignancy in Breast Tissue Samples, 1 year, $100,000
- Craig Roy, Health Research Inc., Coxiella burnetii Type
IV Effector Proteins, 1 year, $163,500
- Gerald Shadel, Robert Leet and Clara Guthrie Patterson Trust, Genetic Transformation of Mitochondria: Toward Mouse Models and Human Gene Therapy for Mitochondrial Diseases and Aging, 1 year, $75,000
- Stefan Somlo, Mizutani Foundation for Glycoscience, The Role of N-Glycosylation in Human Polycystic Diseases, 1 year, $46,442
- Zhaoxia Sun, Edward Mallinckrodt Jr. Foundation, Chemical Suppression of Polycystic Kidney Disease in Zebrafish, 1 year, $50,000
- Flora Vaccarino, Tourette Syndrome Association Inc., Inhibitory Interneurons in the Cerebral Cortex of Patients with Tourette’s Syndrome, 1 year, $74,558
- Li Wen, Juvenile Diabetes Research Foundation International, Tolerance
Induction by Insulin Reactive and TGFß Producing T Cells, 3 years,
$165,000
- Kevin White, Columbia University, Integrated Approaches to Hox-Regulated DNA Elements, 1 year, $131,415
- Graham Williams, Astra Zeneca, L.P., Characterization of the Neurobiological Consequences of Acute Alpha-7 Treatment in the Nonhuman Primate: Identification of the Potential for Improving Cognitive Function in Schizophrenia, 1 year, $230,875
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