Medicine@Yale Magazine

Medicine@Yale.

October/November 2005   Volume 1 Issue 3

Inside this issue

Cover stories

A major boost for recruiting top doctors

Of moths and mice: jumping genes make big leap to mammals

Program aims to close the gender gap in medical research

Partnerships

Yale and Donaghue partnership treats research advances as a practical matter

Students come north and aid flows south as Yale lends a hand in wake of Katrina

Benefit bike ride raises $250,000 for Yale survivors’ clinic

Grants & contracts

People

Lifelines: Gail D’Onofrio on saving and changing lives

Diabetes expert is named dean of nursing

Borgstrom named president/CEO of Yale-New Haven

Neuroscientist Horvath will chair Comparative Medicine

Out & about

Awards & honors

Science

Advances: When it comes to taste, the nose knows | Cellular power plants help explain diabetes

Health

Liver transplantation program formed with an international team of experts

Database promises early alerts of outbreaks

Defusing vascular “time bombs” calls for group effort

New lens implant for cataracts is a bionic-style bifocal

Advances: A stubborn inequity in heart treatments | An upside to aneurysms?



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Grants and contracts awarded to Yale School of Medicine, May/June 2005

Federal

  • Vikki Abrahams, NIH, Innate Immune Responses of Trophoblasts in Pregnancy, 5 years, $1,375,632
  • Anton Bennett, NIH, Myogenesis by Protein Tyrosine Phosphatases, 5 years, $1,798,500
  • Hilary Blumberg, NIH, Genetics of Hippocampal Deficits in Bipolar Disorder, 5 years, $1,704,534
  • Kathleen Carroll, NIH, Maximizing CBT’s Efficacy with Medication and CM, 5 years, $1,700,294
  • Tian Chi, NIH, BAF Complexes in T Cell Development and Beyond, 5 years, $1,982,438
  • Jonathan Dranoff, NIH, Regulation of Bile Ductular Proliferation, 5 years, $1,675,875
  • Gerald Friedland, NIH, New England Program for AIDS Clinical Trial-PROACT, 1 year, $802,492
  • Xiao-Bing Gao, NIH, Crosstalk of Hypocretin and MCH in Feeding Regulation, 5 years, $1,697,814
  • Sankar Ghosh, NIH, Regulation of NF-κΒ Transcriptional Activity, 5 years, $1,982,438
  • Karl Insogna, NIH, Role of CSF-1 in Osteoclast Function, 4 years, $1,466,995
  • Akiko Iwasaki, NIH, Antiviral CTL Mobilization to the Genital Mucosa, 5 years, $1,982,438
  • Susan Kaech, NIH, Regulation of Memory CD8 T Cell Development, 5 years, $1,982,438
  • Harriet Kluger, NIH, Predicting Melanoma Response to BAY 43-9006/Chemotherapy, 4 years, $1,150,267
  • Brian Leaderer, NIH, Indoor and Outdoor NO2 and Asthma Severity in Children, 5 years, $403,509
  • Thomas McGlashan, NIH, Collaborative Longitudinal Study of Personality Disorder, 4 years, $1,005,782
  • Sherry McKee, NIH, Negative Affect and Smoking Behavior in Women and Men, 2 years, $394,885
  • Sukanya Narasimhan, NIH, Early Tick Salivary Antigens as Vaccine Targets, 2 years, $440,100
  • Godfrey Pearlson, NIH, fMRI Imaging of Alcohol-Intoxicated Driving, 4 years, $973,672
  • Vincent Quagliarello, NIH, Intervention Planning to Reduce Nursing Home Pneumonia, 1 year, $165,356
  • David Rimm, NIH, Predicting Metastasis to Lymph Nodes, 4 years, $1,033,320
  • Michael Robek, NIH, Modulation of HBV Replication by the Immunoproteasome, 2 years, $268,000
  • Gerard Sanacora, NIH, 13C Measurement of GABA Synthesis in Depression, 5 years, $1,698,705
  • David Schatz, NIH, Targeting of Somatic Hypermutation and Gene Conversion, 2 years, $449,625
  • Albert Shaw, NIH, Top3 Homologues in Lymphocyte Genome Stability and Aging, 5 years, $355,175
  • David Stern, NIH, Protein Kinases in Yeast DNA Checkpoint Pathways, 5 years, $1,364,264
  • Brian Wong, NIH, Mechanisms of Drug Resistance in Candida albicans, 3 years, $968,420

With funding from the National Institutes of Health, Akiko Iwasaki, assistant professor of immunobiology, studies immune responses to herpes simplex virus type 2 (HSV-2) infection, one of the most common sexually transmitted diseases. In this section of mouse vaginal tissue, immune-system cells (green) are seen in proximity to cells infected with HSV-2 (red).


Non-Federal

  • Diana Beardsley, RAM Capital Group, LLC, Perinatal Immune Thrombocytopenia, 1 year, $239,766
  • Alfred Bothwell, L2 Diagnostics, LLC, Protection Against West Nile Virus by RNA Interference, 2 years, $292,188
  • Janet Brandsma, Anacor Pharmaceuticals, Screening Anacor Compounds for in vivo Efficacy in the Cottontail Rabbit Papillomavirus (CRPV) Assay, 1 year, $151,952
  • Michael Cappello, University of California - San Diego, Function/Optimization of a Nematicidal Cry Toxin Arsenal, 4 years, $23,643
  • Sonia Caprio, Children’s Hospital, Boston, Health Values and Treatment of Pediatric Type 2 Diabetes, 1 year, $1,890
  • Idil Cavus, The Epilepsy Project, Controlling Brain Excitability by Electrical Stimulation, 1 year, $100,000
  • Gina Chung, Susan G. Komen Breast Cancer Foundation, The Role of Chemokines and Their Receptors in Breast Cancer, 3 years, $249,999
  • R. Todd Constable, Pfizer Inc., Magnetic Resonance Imaging for Non-Invasive Characterization of Liver Fibrosis, Cirrhosis, and Hemodynamics with Application to Other Organs, 1 year, $356,127
  • Ronald Duman, Organon Inc., Influence of Org 2448 and Org 26576 on Neurogenesis in Adult Hippocampus, 1 year, $221,160; National Alliance for Research on Schizophrenia and Depression, Proliferation and Survival of Glia: Regulation by Stress and Antidepressants, 1 year, $100,000
  • John Geibel, AstraZeneca, A.B., Multi-Tissue Analysis of AstraZeneca’s Compound Coded as AZD0865, 6 months, $150,722
  • Joel Gelernter, Medical University of South Carolina, Florida Hurricanes and Older Adults: Outcomes/Resiliency, 2 years, $13,040
  • Harriet Kluger, Breast Cancer Alliance Inc., Prediction of Lymph Node Involvement in Breast Cancer, 2 years, $60,000
  • Harlan Krumholz, Mid America Heart Institute, SCCOR in Cardiac Dysfunction and Disease-Project 4, 4 years, $114,524
  • Daniel Mathalon, American Psychiatric Association, APIRE/Kemp Fund Award for Research, 2 years, $21,500
  • Russell Matthews, University of Georgia, GicNAcT-V Regulation of Cell Surface Structure/Function, 5 years, $100,757
  • Linda Mayes, Community Foundation for Greater New Haven, Minding the Baby Home Visiting Program for First-Time Parents, 1 year, $20,000
  • Diane McMahon-Pratt, Fort Dodge Animal Health Division of Wyeth, Visceral Leishmaniasis Vaccine Efficacy in Intradermal BALB/C Mouse Model, 2 years, $115,000
  • Wang Min, AtheroGenics Inc., AtheroGenics Testing Agreement, 1 year, $45,000
  • Guillermo Mor, Wayne State University, Studies of Toll-Like Receptors and Apoptosis in the Maintenance of Innate Immunity During Pregnancy, 1 year, $133,854
  • Alexander Neumeister, Anxiety Disorders Association of America, Genetic Determinants of Noradrenergic Function in Panic Disorder, 1 year, $30,000
  • Scott Rivkees, March of Dimes, Prevention of Brain Injury of Prematurity by Prenatal Adenosine Antagonists, 1 year, $264,779
  • Sara Rockwell, Susan G. Komen Breast Cancer Foundation, Interactions of Black Cohosh Extracts with Doxorubicin: Possible Mechanisms, 2 years, $250,000
  • Nenad Sestan, March of Dimes, Molecular and Cellular Characterization of Dominant Ataxia with Hydrocephalus in the Clumsy Mutant Mouse, 3 years, $229,014
  • Mark Solomon, March of Dimes, Substrates of the Anaphase Promoting Complex, 3 years, $263,652
  • Stephen Strittmatter, Dr. Ralph and Marian Falk Medical Research Trust, Axonal Regeneration Therapy for Spinal Cord Injury, 3 years, $975,000
  • Patrick Sung, Susan G. Komen Breast Cancer Foundation, Role of BRCA2 in Homology-Directed Repair of DNA Breaks, 2 years, $250,000
  • Agnes Vignery, Unigene Laboratories Inc., Targeted Induction of Bone Formation in vivo, 3 years, $739,360
  • Fred Volkmar, Oregon Health Sciences University, Measuring Expressive and Receptive Prosody in Children with Autism, 4 years, $137,670
  • Sherman Weissman, University of Massachusetts, Gene Expression in Mature Neutrophils, 4 years, $285,618
  • Jason Wilken, Elsa U. Pardee Foundation, Inhibitory Potential of SErbB3: A Soluble ErbB3 Isoform, 1 year, $30,000
  • Scott Woods, National Alliance for Research on Schizophrenia and Depression, Glycine vs. Placebo in Patients with Schizophrenia, 1 year, $100,000
  • Derek Yach, Open Society Institute, Reducing Deaths from Tuberculosis and Tobacco Together, 1 year, $70,000
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Copyright 2005, Yale University School of Medicine. All rights reserved. Email comments or suggestions to: editor@info.med.yale.edu.