Medicine@Yale publication

Medicine@Yale.

July/August 2006  Volume 2 Issue 4

Inside this issue

Cover stories

A love of Yale, a vision for its future

A faster pipeline speeds new treatments from lab to patient

“Teacher’s teacher” to oversee curriculum as education dean

Partnerships

Biology, medicine unite in new grad initiative

Grants & contracts

People

Pioneer of antiviral therapies is awarded the Parker Medal, school’s highest honor

Expert on autism is named new director of Child Study Center

Blood cell researcher is named new chair of Laboratory Medicine

Yale biochemist is elected to the world’s oldest scientific society

Lifelines: Rebel with a cause

Out & about

Awards & honors

Education

Superb teaching is rewarded at graduation

Science

New protein chips are a window on the womb

An eye for science

Advances: Trading life and limb in pursuit of being thin | How immunity is MIFfed by malaria | Placenta may hold autism's earliest mark| Curbing the scourge of deadly diarrhea



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Pioneer of antiviral therapies is awarded the Parker Medal, school’s highest honor

Anti-HIV/AIDS compound discovered by awardee has improved lives worldwide

William Prusoff and Robert Alpern photo

William Prusoff (left), a trailblazer in pharmacology, receives the Peter Parker Medal from Dean Robert Alpern.

The Peter Parker Medal, the School of Medicine’s premier award, is named for an intrepid alumnus and graduate of the Yale Divinity School who traveled to China in 1834 as a medical missionary. By founding the Ophthalmic Hospital at Canton, the Reverend Peter Parker, M.D., set the stage for the extraordinarily close and wide-ranging ties between Yale and China that endure to the present day.

The 2006 recipient of the Peter Parker Medal, William H. Prusoff, Ph.D., spent his working life at the lab bench instead of the bedside, but his contributions, like Parker’s, have had a lasting global impact.

In the 1950s, Prusoff, now professor emeritus and senior research scientist in the Department of Pharmacology, synthesized the first antiviral compound approved for human use by the Food and Drug Administration (FDA).

But he is best known for research conducted during the 1980s with his late colleague Tai-Shun Lin, Ph.D., on d4T, a potent treatment for HIV/AIDS. Under the trade name Zerit, d4T forms part of the three-drug “cocktail” that has extended the lives of tens of thousands of people with HIV/ AIDS worldwide.

In a landmark decision in 2001, Bristol Myers Squibb, which developed and markets Zerit, agreed to distribute the drug at no profit to HIV/AIDS patients in the hard-hit countries of sub-Saharan Africa. Royalties to Yale from sales of Zerit in developed countries provided the lion’s share of funding for the construction of the Anlyan Center for Medical Research and Education, which houses state-of-the-art laboratories and classrooms at the School of Medicine.

Prusoff joined the medical school faculty in 1953. He received his undergraduate degree in chemistry from the University of Miami, his doctorate from Columbia University and an honorary doctorate from the University of Cagliari in Italy in 1989.

In 2000 the School of Medicine established the William H. Prusoff Professorship in Pharmacology in Prusoff ’s honor, a post now held by the Chair of the Department of Pharmacology, Joseph Schlessinger, Ph.D.

Prusoff “exemplifies the Yale researcher,” said Dean and Ensign Professor Robert J. Alpern, M.D., at an April ceremony and celebration at New Haven’s Union League Café marking the award of the Parker Medal. “I am proud and thankful for Dr. Prusoff’s ambassadorship on behalf of this institution.” image


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