Two images made by Cécile M. Chalouni, Ph.D., associate research scientist in the laboratory of Ira Mellman, Ph.D., Sterling Professor of Cell Biology. Left: Confocal micrograph of a mature in vitro-derived human dendritic cell, a professional antigen-presenting cell of the immune system, made in collaboration with Jean Davoust, Ph.D., of Généthon, Evry, France. This cell, derived from blood CD11c progenitor, is labeled for the antigen-presentation molecule HLA-DR (dark blue), which is strongly expressed on its cell surface. Below: Confocal image of a section of human colon labeled to visualize actin filaments (green) and the adhesion molecule A33 (red) located on the basolateral membranes of the colon epithelial cells. Cell nuclei are labeled by the TO-PRO-3 dye (blue).

Indirect immunofluorescence on polarized rat hepatocytes cultured in a sandwich of collagen gel by Wei Wang, Ph.D., associate research scientist in the Department of Medicine and imaged on a confocal microscope by Carol J. Soroka, Ph.D., research scientist in the Department of Medicine. The apical bile canalicular membrane is seen in green, the basolateral membrane in red and cell nuclei in blue. Both Wang and Soroka are affiliated with the Yale Liver Center.

A section of mouse cerebellum imaged with laser scanning microscopy by Valeswara-Rao Gazula, Ph.D., associate research scientist in the Department of Pharmacology, and Sudhakar Ravuri, Ph.D., of the medical school’s W.M. Keck Foundation Biotechnology Resource Laboratory. Receptors for the neurotransmitter acetylcholine in the cerebellum’s Purkinje cells are seen as red and DNA is labeled green.