Inside this issue

Cover stories

New PET Center will aid drug development

A 'country doctor' gives back to Yale by aiding students

Partnerships

High school partnership celebrates 10 years

People

Cell-signaling expert will lead vascular biology

Medical oncologist is appointed deputy director of Cancer Center

Immunobiology chair is named to Institute of Medicine

Scientist is honored by foundation for research on lupus

Science

Immunology comes of age at medical school

Yale research makes Science's 'top 10' list

Advances: Breathing easier about lung injury? | Changes in Medicare help prevent cancers | Inclined by genes toward nicotine | Missing molecule puts neurons off track

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Grants and contracts awarded to Yale School of Medicine, July/August 2006

Federal

With support from the National Institutes of Health, Hal Blumenfeld, M.D., Ph.D., associate professor of neurology, neurobiology and neurosurgery, is performing neuroimaging studies of epilepsy. This image shows brain areas involved in absence seizures in a 12-year-old girl.

• Hervé Agaisse, NIH, High-Throughput Screen for Compounds Affecting Intracellular Pathogen Infection, 1 year, $82,500

• Robert Beech, NIH, A Genetic Model for the Role of Neurogenesis in Antidepressant Response, 2 years, $379,125

• Andrea Benin, NIH, Outpatient EHRs: Using Electronic Data to Improve Health and Health Care, 3 years, $486,000

• Zubin Bhagwagar, National Alliance for Research on Schizophrenia and Depression, A Proton MRS Study of GABA and 5-HT Interactions, 2 years, $60,000

• Daniel Biemesderfer, NIH, Megalin Function in the Normal and Diseased Kidney, 5 years, $1,694,325

• Hal Blumenfeld, NIH, Functional Neuroimaging in Childhood Absence Epilepsy, 3.5 years, $1,889,682

• Arthur Broadus, NIH, PTHrP Function in the Periosteum and Entheses, 2 years, $330,000

• Robert Bruce, NIH, Substance Abuse, HIV and HVC Treatments to Improve Health Outcomes in Drug Users, 5 years, $870,852

• Sonia Caprio, NIH, Pathophysiology of Metabolic Defects of Juvenile Obesity, 5 years, $916,605

• Judy Cho, NIH, IBD Consortium Genetics Research Center, 1 year, $319,573; NIH, IBD Genetics Consortium Data Coordinating Center, 1 year, $922,200

• R. Todd Constable, NIH, Towards an Improved Understanding of BOLD Signal Changes, 5 years, $1,847,260

• Nihal Delanerolle, NIH, Proteomic Profiles in Human Temporal Lobe Epilepsy, 2 years, $408,375

• Caroline Easton, NIH, A Therapy Approach for SADV, 3 years, $873,000

• Erol Fikrig, NIH, Immunotherapeutics for Treatment of Flavivirus Infection, 5 years, $6,982,520

• Durland Fish, U.S. Department of Agriculture, Northeast Regional Tick Control Project, 1 year, $208,544

• Terri Fried, NIH, Treatment Goals at the End of Life, 3 years, $1,272,050

• Frank Giordano, NIH, Zinc Finger Proteins to Modify Heart Function, 5 years, $2,066,250

• Charles Greer, NIH, Neuron Glial Interactions, 5 years, $1,575,361

• Ruth Halaban, NIH, Yale SPORE in Skin Cancer, 5 years, $11,500,000

• Graeme Hammond, NIH, MHC Suppression as a Model for Transplant Tolerance, 2 years, $453,750

• Kevan Herold, NIH, Phase II Trial of HoKT3y, 4 years, $2,157,201

• Margaret Hostetter, NIH, Developmental Adaptation: Child Health Research Center, 4 years, $2,106,443

• Jeannette Ickovics, NIH, Integrating Prenatal Care to Reduce HIV/STDs Among Teens: A Translational Study, 5 years, $4,511,882

• Mustafa Khokha, NIH, Role of Gremlin in Embryonic Development, 1 year, $121,770

• Diane Krause, NIH, Epithelial Engraftment of Bone Marrow Derived Stem Cells, 3 years, $743,500

• Daeyeol Lee, NIH, Dynamics and Neural Mechanisms of Decision Making, 1 year, $56,110

• Douglas Leslie, NIH, Patterns of Service Use and Costs Associated with Autism, 3 years, $586,800

• Ming Li, NIH, TGF-beta 1 Regulation of Peripheral T Cell Tolerance, 5 years, $691,200

• Annette Molinaro, NIH, Statistical Methods for Predicting Survival Outcomes from Genomic Data, 3 years, $478,269

• Dhasakumar Navaratnam, NIH, Studies on Hair Cell BK Channels,5 years, $1,859,625

• Laura Niklason, NIH, Novel Cellular Life Span Extension for Tissue Engineering, 1 year, $187,977

• Michael Nitabach, NIH, Transgenic Tethered Spider Toxins, 4.5 years, $1,815,282

• Peter Novick, NIH, Genetics of Secretion in Yeast, 5 years, $2,182,490

• J. Peter Olausson, Nat’l Alliance for Research on Schizophrenia and Depression, Reinforcement of Neuroprotection for Stress Hormone-Induced Hippocampal Damage by FGF Signaling Pathways, 2 years, $60,000

• Godfrey Pearlson, NIH, Reward, Impulsivity and Cocaine Addiction: fMRI Studies, 4 years, $1,618,069

• Marina Picciotto, NIH, Antidepressant Effect of Nicotinic Receptor Blockade, 10 months, $1,580,604

• Douglas Rothman, NIH, Acquisition of a 7T Human MR System for the Development of Ultra High Resolution Whole Brain MRSi and MRI, 1 year, $2,000,000

• David Rothstein, NIH, Peripheral Mechanisms of Immunologic Tolerance, 5 years, $7,039,959

• Gerard Sanacora, NIH, Studies of Amino Acid Neurotransmitter Contributions to Depression, 5 years, $634,230

• Alan Sartorelli, NIH, Hypoxia-Activated O6 Benzylguanine Prodrugs, 3 years, $880,401; NIH, Development of Anticancer 1.2-Bis(sulfonyl)hydrazines, 4 years, $1,214,240

• Samuel Sathyanesan, NIH, Choroid Plexus and Antidepressants: Genomics and Proteomics, 2 years, $337,582

• Nenad Sestan, Nat’l Alliance for Research on Schizophrenia and Depression, Characterization of a Novel Candidate Gene in Schizophrenia, 2 years, $60,000

• Eugene Shapiro, NIH, Effectiveness of Vaccines in Clinical Practice, 5 years, $760,280

• Mark Shlomchik, NIH, Role of B Cells and DCs in Lupus Pathogenesis, 5 years, $2,339,919

• Warren Shlomchik, NIH, Dendritic Cell Subsets and Paths of Maturation in GVHD, 5 years, $2,066,250

• Julie Staley-Gottschalk, NIH, Cognition, Tobacco Smoke and Nicotinic Receptor Occupancy, 1.5 years, $336,257

• Thomas Steitz, NIH, Structure of DNA and RNA Polymerases and their Functional Complexes, 4 years, $1,564,921

• Lisa Suter, NIH, The Cost-Effectiveness of MRI in Early Rheumatoid Arthritis, 5 years, $663,525

• Eugene Swenson, NIH, Liver Injury and Repopulation by Bone Marrow Stem Cells, 5 years, $671,290

• Hemant Tagare, NIH, Segmentation of Ultrasound Images, 4 years, $1,556,175

• Cenk Tek, Nat’l Alliance for Research on Schizophrenia and Depression, Mental Transformations in Schizophrenia in Relation to Negative Symptoms and Deficit Syndrome, 2 years, $59,992

• Benjamin Turk, U.S. Department of the Army, Identification of Substrates and Inhibitors of the Anthrax Lethal Factor, 1 year, $259,928

• Sandra Wolin, NIH, Antibodies to Ro Ribonucleoproteins as Biomarkers in Sjogren’s Syndrome, 2 years, $431,122

Non-Federal

• Jonathan Bogan, W. M. Keck Foundation, Regulation of Glucose Transporter Trafficking, 5 years, $1,000,000

• Titus Boggon, American Society of Hematology, Structure/Function Studies of Janus Jinase Family Members, 2 years, $150,000

• Elizabeth Bradley, John D. Thompson Hospice Institute for Education, Training and Research, Inc., Improving Care for Patients with Irreversible Conditions and Their Families, 1 year, $100,000

• Pia Britto, Russell Sage Foundation, Man Ana: An Investigation of Ethnic Identity Formation of Muslim Arab Children in the United States, 2 years, $103,510

• Herta Chao, American Association for Cancer Research, The Detection of Pharmacodynamic Changes in Circulating Tumor Cells in Response to Chemotherapy Using Novel Robotic Epifluorescent Microscopy Platform, 2 years, $100,000

• Katarzyna Chawarska, Autism Speaks, Face and Gaze Processing in the Second Year of Life: Comparison between ASD, DD and Typical Infants, 2 years, $119,979; Autism Speaks, Why and When Do Children with Autism Develop Difficulties Recognizing Faces?, 2 years, $100,000

• Haijun Chen, American Heart Association, The Molecular and Structural Basis of Beta-Subunits MinK and MiRP1, 4 years, $260,000

• Lei Chen, Ambulatory Pediatric Association, Training of Pre-Hospital Personnel in the Use of Laryngeal Mask Airways in Simulated Pediatric Arrest Scenarios, 1 year, $8,000

• Hongbo Chi, Arthritis Foundation, Regulation of Immune Response and Systemic Autoimmunity by SIP Signaling, 2 years, $150,000

• Susan Compton, ACLAM Foundation, Murine Norovirus Pathogenesis and Transmissibility, 1 year, $24,998

• R. Todd Constable, The John B. Pierce Laboratory Inc., Cognitive and Affective Influences on Central Taste Processing, 5 years, $100,707

• Vladimir Coric, Obsessive Compulsive Foundation, Inc., A Double-Blind, Placebo Controlled Trial of N-Acetylcysteine in SRI-Resistant OCD, 1 year, $36,600

• Priscilla Dannies, Elsa U. Pardee Foundation, Enhancing the Ability of Human Growth Hormone to Reduce Tumor Burden in a Mouse Model of Human Ovarian Cancer, 1 year, $131,631

• Alan Dardik, American Vascular Association, Flow Responses to Carotid Angioplasty, 1 year, $75,000

• Enrique De La Cruz, American Heart Association, Actin Filament Cooperativity and Actin Binding Protein Function, 3 years, $198,000

• Ronald Duman, Sepracor Inc., Influence of Eszopiclone on Neurogenesis and Cell Proliferation in Adult Limbic Brain Structures, 1 year, $80,025

• Richard Flavell, American Diabetes Association, Inc., Prevention of Type 1 Diabetes by tgf-Beta-Induced Regulatory T Cells, 3 years, $300,000

• Gerald Friedland, University of Natal, Collaborative AIDS Program of Research in South Africa (CAPRISA), 1 year, $19,282

• David Geller, American Heart Assoc. (Heritage Affiliate), Renal and Extrarenal Effects of Aldosterone, 3 years, $198,000; Amgen Nephrology Institute, Molecular Mechanisms of Hypertension in the Metabolic Syndrome, 1 year, $58,868

• Satish Ghatpande, Charles H. Hood Foundation, Novel Mechanisms of Embryo Protection: The Role of Adenosine Action in the Developing Heart, 2 years, $150,000

• Daniel Goldstein, Society of Geriatric Cardiology, Role of Aging in Vascular Injury, 1 year, $10,000

• Fred Gorelick, Brentwood Biomedical Research Inst., Alcohol and the Exocrine Pancrease ER Stress Responses, 1 year, $32,600

• Jonathan Grauer, Medtronic, Inc., Modeling the Deleterious Effect of Infection on Posterolateral Lumbar Fusion in a Rabbit Model and Evaluating the Potential Effect of BMP2 to Overcome this Effect, 1 year, $155,362

• Kalpana Gupta, The Patrick and Catherine Weldon Donaghue Medical Research Foundation, Cranberry for UTI Prevention in Nursing Home Residents, 2 years, $238,710

• Bryan Hains, International Association for the Study of Pain, Sodium Channel Blockers and Pain after Spinal Cord Injury, 1 year, $5,000

• James Hill III, Albert Einstein Healthcare Network, The Impact of Healthy Work Organization on Return to Work Outcomes in an Aging Workforce, 3 years, $190,374

• Selby Jacobs, State of Connecticut Department of Mental Health and Addiction Services, PCP: Person-Centered Care for Psychosis, 1 year, $432,166

• Sven-Eric Jordt, State of Connecticut Department of Public Health, Sensory Irritant Receptors in the Pathogenesis of Smoking-Induced Lung Disease, 2 years, $299,723

• Anil Karihaloo, American Heart Assoc. (Heritage Affiliate), Role of VEGF in Renal Ischemic Repair, 3 years, $198,000

• Haifan Lin, Stem Cell Research Foundation, Translation Regulation of Stem Cell Self-Renewal, 2 years, $80,575

• Kangmo Lu, American Diabetes Association, Inc., New Risk Factors for Diabetic Retinopathy, 1 year, $100,000

• James Macy, ACLAM Foundation, Strategies for MPV Screening, 1 year, $25,000

• Arya Mani, American Heart Assoc. (Heritage Affiliate), Mapping a Gene for Premature Coronary Artery Disease, 3 years, $198,000

• Ira Mellman, Sandler Program for Asthma Research, Dendritic Cell Biology and Asthma, 3 years, $750,000

• Guillermo Mor, The Johns Hopkins University, Multiplex Protein Test for Early Detection of Ovarian Cancer, 1 year, $50,000

• Laura Niklason, Texas A&M University, Ex Vivo Delineation of Mechanisms of Cerebral Vasospasm, 3 years, $89,182

• Marcella Nunez Smith, Robert Wood Johnson Foundation, Minority Faculty in Academic Medicine: How to Successfully Support Diversity, 1 year, $49,868

• A. David Paltiel, Massachusetts General Hospital, The Cost-Effectiveness of Preventing HIV Complications,1 year, $22,287

• Chirag Parikh, American Heart Assoc. (Heritage Affiliate), A Pilot Study Investigating Novel Biomarkers in Cardiac Surgery to Detect Acute Kidney Injury, 1 year, $74,931; The Patrick and Catherine Weldon Donaghue Medical Research Foundation, Novel Biomarkers to Detect Delayed Graft Function, 3 years, $197,144; Satellite Healthcare, Inc., The Diagnostic and Prognostic Value of Biomarkers for Acute Kidney Injury in Critically Ill Patients, 3 years, $150,000

• Albert Perrino, Alcoholic Beverage Medical Research Foundation, Heightened Pain Processing in Individuals at Risk for Alcoholism, 6 months, $40,000

• Edward Perry, Alcoholic Beverage Medical Research Foundation, Interactive Psychopharmacologic Effects of Alcohol and Nicotine in Humans, 2 years, $90,000

• George Porter, Charles H. Hood Foundation, Calcium Channels Regulate the Formation of the Cardiac Outflow Tract from the Anterior Heart Field, 2 years, $150,000

• Nandhini Ramamoorthi, Arthritis Foundation, Tick Salivary Protein, Salp 15 and Control of Lyme Arthritis, 2 years, $150,000

• Jill Reiter, Breast Cancer Alliance, Inc., Quantitative Analysis of EGFR Variants in Breast Cancer, 2 years, $125,000

• Scott Rivkees, Chemical Diversity Labs, Inc., Identification of Novel ACTH Antagonists, 1 year, $183,356

• Haleh Saadat, Foundation for Anesthesia Education Research, Implementation and Testing of a Wellness Program Conducted with Anesthesiology Residents at Yale, 2 years, $100,000

• Robert Sherwin, American Diabetes Association, Inc., CNS Responses to Hypoglycemia in Diabetes, 4 years, $180,000

• Warren Shlomchik, The Leukemia & Lymphoma Society, Memory T Cells for Immune Reconstitution Post-Allogenic Stem Cell Transplantion, 5 years, $550,000

• Peter Smith, ACLAM Foundation, Mouse Parvovirus: Effects of Immune Status and Pregnancy on Duration and Potential Reactivation of Viral Shedding, 1 year, $25,000

• Julie Sosa, American Geriatrics Society, A Multi-Institutional Randomized Controlled Trial Measuring the Effects of Surgery on Depression, Memory and Concentration Among Elderly Patients with Asymptomatic Primary Hyperparathyroidism, 2 years, $150,000

• Matthew State, Tourette Syndrome Association, Inc., Investigation of SLIT and Trk-Like Family 1 (SLTRK1): A New Candidate Gene for Tourette Syndrome, 1 year, $75,000

• Meredith Stowe, The Patrick and Catherine Weldon Donaghue Medical Research Foundation, Reducing Isocyanate Exposure in the CT Autobody Industry, 3 years, $91,180

• Lynn Sullivan, Robert Wood Johnson Foundation, Reducing HIV Sexual Risk Behaviors in Patients Receiving Treatment for Opioid Dependence, 3 years, $46,183

• Lisa Suter, Arthritis Foundation, Defining Best Practices for MRI in Rheumatoid Arthritis, 2 years, $150,000

• Ning Tian, Research To Prevent Blindness, Inc., Research to Prevent Blindness Dolly Green Scholar, 1 year, $70,000

• Susumu Tomita, Esther and Joseph Klingenstein Fund, Inc., Regulation of Excitatory Synaptic Strength in the Brain, 3 years, $150,000

• Elizabeth Triche, State of Connecticut Department of Public Health, Genetics and Smoking in Pregnancy, 2 years, $349,893

• Marianne Ulcickas Yood, Henry Ford Health System, Oral Antidiabetic and Insulin Use Among Patients with Diabetes, 2 years, $35,000

• Jack Van Hoff, St. Baldrick’s Foundation, St. Baldrick’s Foundation Award, 1 year, $25,000

• Joanne Weidhaas, State of Connecticut Department of Public Health, Analysis of miRNA Mutations in Lung Cancer, 2 years, $265,050

• Stuart Weinzimer, Juvenile Diabetes Research Foundation International, Advanced Studies of Closed Loop Glucose Control on Type 1 Diabetes, 2 years, $618,082

• Erin Wolff, University of California—San Francisco, Regulation of HOXA 10 by Putative Co-Factor Spastin, 1 year, $119,450

• Xuchen Zhang, American Heart Assoc. (Heritage Affiliate), Role of HO-1 and STAT3 in Oxidant-Induced Lung Injury, 3 years, $198,000

Medicine@Yale publication

March/April 2007 Volume 3 Issue 2