Medicine@Yale publication

Medicine@Yale.

September/October 2007   Volume 3 Issue 5

Inside this issue

Cover stories

Giving back

$23 million grant enables fresh look at stress and addiction

The many sides of stress and addiction

Lightening the load for the physicians of the future

Partnerships

Transatlantic team probes kidney’s role in hypertension

Grants & contracts

People

Lifelines: James Duncan

Lyme disease expert is new section chief and Hughes investigator

Dean for education is appointed Jockers Professor

Student-run clinic wins Ivy Award for community service

Out & about

Awards & honors

Science

A joint effort to tackle obesity and diabetes

Growing spare parts for sick children’s hearts

Advances: Breaking away from child abuse? | For cardiac surgery, your brain on ice | Mom was right: eat your vegetables! | “Touch-me-not” tubes kill bacteria



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Grants and contracts awarded to Yale School of Medicine

January/February 2007

Federal

Haifan Lin, Governor M. Jodi rell and J. Robert Galvin

In April, Haifan Lin (left), director of the Yale Stem Cell Center, accepted a check for $7.7 million from the Connecticut Stem Cell Research fund from Connecticut Governor M. Jodi Rell (center) and J. Robert Galvin, commissioner of the Connecticut Department of Public Health.

  • Roland Baron, NIH, From Adhesion to Bone Resorption: The Role of Dynamin in Osteoclasts, 5 years, $1,777,602
  • Alfred Bothwell, NIH, Revascularization of Islets to Treat Type 1 Diabetes, 2 years, $412,792
  • William Bradley, NIH, Adhesion-Dependent Inhibition of RhoA through Arg Tyrosine Kinase and p190RhoGAP, 3 years, $91,629
  • Suzanne Cassel, NIH, Role of Lung Inflammation in Th2 Priming, 5 years, $492,480
  • Junjie Chen, NIH, Analysis of 53BP1 Function in DNA Damage Signaling Pathway and Tumorigenesis, 4 years, $1,551,712
  • Kevin Collins, NIH, Heterotrimeric G-Protein Regulation of Neurotransmission in C. elegans, 3 years, $141,318
  • Michael Crair, NIH, Mechanisms of Visual Map Development, 2.5 years, $779,670
  • Isabelle Derre, NIH, RNAi Screen to Identify Host Factors Involved in Chlamydia Pathogenesis, 2 years, $412,792
  • Tore Eid, NIH, Temporal Lobe Epilepsy—Validation of a New Animal Model, 2 years, $397,259
  • Alison Galvani, NSF, Collaborative Research: Modeling and Behavioral Evaluation of Social Dynamics in Prevention Decisions, 3 years, $377,485
  • Charles Greer, NIH, Odorants, Receptors and Glomeruli, 1.5 years, $1,289,556
  • Lyndsay Harris, Department of Defense, Molecular Classifications of Response to Therapy in HER2 Positive, Early-Stage Breast Cancer, 2.25 years, $994,847
  • Raimund Herzog, NIH, Adaptations of CNS Metabolism to Hypoglycemia in Diabetes, 2 years, $116,072
  • Hoby Hetherington, NIH, MRS Measurements of GABA in Temporal Lobe Epilepsy, 1.25 years, $320,151
  • Tamas Horvath, NIH, Ghrelin in Hypothalmic Regulation of Energy Balance, 4 years, $1,289,357
  • James Howe, NIH, Single Channel Properties and Structure of Glutamate Receptors, 4 years, $1,446,394
  • Ruslan Medzhitov, NIH, TLRs in Host-Commensal Interactions, 4 years, $1,355,648
  • George Richerson, NIH, Developmental Defects in Serotonin Neurons and the Response to O2 and CO2, 5 years, $1,657,482
  • Joseph Santos-Sacchi, NIH, Structural Correlates of Prestin Activity, 3 years, $1,053,470
  • Dieter Söll, NSF, Expanding the Genetic Code with Phosphoserine, 3 years, $522,375
  • Scott Strobel, NSF, International: Undergraduate Rainforest Expedition and Laboratory, 2 years, $60,000
  • Zhaoxia Sun, Department of Defense, TSC1 and the Cilium in Zebrafish Kidney, 2 years, $221,100
  • Fayyaz Sutterwala, NIH, The Role of NALPs in Innate Immunity, 4 years, $504,280
  • David Willhite, NIH, Transsynaptic Tracing of Olfactory Bulb Input to the Olfactory Cortex, 3 years, $247,895

Non-Federal

  • Ali Abu-Alfa, Abbott Laboratories Inc., Educational Grant for Chronic Kidney Disease Center of Excellence, 1 year, $40,250
  • Maysa Abu-Khalaf, Breast Cancer Alliance, Inc., An Integrated Approach to Biomarker Validation in Patients with HER-2 Positive Metastatic Breast Cancer Treated with Rapamycin (Rapamune) to Overcome Resistance to the HER-2 Targeted Therapy Trastuzum, 2 years, $125,000
  • Karen Anderson, Albert Einstein College of Medicine, The Role of Viral and Cellular Proteins in Early Events of HIV-1 Replication, 5 years, $82,500
  • Michael Bloch, American Academy of Child and Adolescent Psychiatry, Clinical and Volumetric MRI Predictors of the Adult Outcome in Pediatric Obsessive-Compulsive Disorder, 1 year, $9,000
  • Hal Blumenfeld, The Patrick and Catherine Weldon Donaghue Medical Research Foundation, Impaired Consciousness in Epilepsy: Mechanisms and Consequences, 5 years, $595,791
  • Judson Brewer, The Mind & Life Institute, Mindful Training as Treatment and Mechanistic Probe for Drug Addiction, 1 year, $10,000
  • Stacy Castner, Pfizer Inc., Discovery Proposal for Nonhuman Primate Models Relevant to Schizophrenia, 1 year, $374,617
  • Katarzyna Chawarska, Autism Speaks, Computational Modeling of Visual Attention in Young Children with ASD, 2 years, $54,000
  • Michael Chen, American Society of Maxillofacial Surgeons, National Outcomes Studies in Craniofacial Surgery, 1 year, $6,680
  • Judy Cho, Burroughs Wellcome Fund, Characterization of Expression Patterns in Monocyte-Derived Cells in Inflammatory Bowel Disease, 1 year, $75,000
  • Dylan Clyne, Robert Leet and Clara Guthrie Patterson Trust, Neuronal Control of Courtship in Drosophila, 2 years, $104,000
  • James Comer, Nellie Mae Education Foundation, Nellie Mae Directors Grant, 1 year, $20,000
  • David Cone, The Laerdal Foundation for Acute Medicine, Virtual Reality for Disaster Triage Research, 1 year, $12,260
  • Michael Crair, Rett Syndrome Research Foundation, Examining the Role of MeCP2 in Regulating the Plasticity and Development of Synapses and Circuits in Mouse Somatosensory Barrel Cortex, 3 years, $100,000
  • Daryn David, The International Psychoanalytical Association, Investigating the Internal Working Model Concept, 1 year, $4,000
  • Nancy Dunbar, Endocrine Fellows Foundation, Characterization of Cystic Fibrosis Bone Disease Using Three Mouse Genetic Models, 1 year, $7,500
  • John Forrest, Doris Duke Charitable Foundation, International Clinical Research Fellowships (ICRF) in Africa Pilot Program, 1.5 years, $130,000
  • Gerald Friedland, University of Connecticut, Integrating HIV Prevention into Clinical Care for PLWHA in South Africa, 5 years, $217,999
  • Anna-Rachel Gallagher, PKD Foundation for Research in Polycystic Kidney Disease, Pathogenesis of Congenital Hepatic Fibrosis and Biliary Cyst Formation in ARPRD, 1 year, $75,000
  • Alan Garen, Prostate Cancer Foundation, Targeted Nanoparticles to Deliver the Icon Gene for Prostate Cancer Immunotherapy, 1 year, $100,000
  • Kim Good, Arthritis Foundation of Australia, Role of B7 Family Members in Enhanced Secondary Immune Responses, 1 year, $38,798
  • Carlos Grilo, The Patrick and Catherine Weldon Donaghue Medical Research Foundation, RCT for Obesity and Binge Eating in Monolingual Hispanic Persons, 3 years, $239,997
  • Bryan Hains, Mike Utley Foundation, Rescuing Motor Function after Spinal Cord Injury, 1 year, $47,833
  • Kevan Herold, Juvenile Diabetes Research Foundation Int’l, Islet Growth in NOD Mice Tolerant to Autoimmune Diabetes, 3 years, $495,000; Juvenile Diabetes Research Foundation Int’l, Mechanistic Studies and Identification of Biomarkers in Patients with T1DM, 4 years, $660,000
  • Melinda Irwin, American Cancer Society, Inc., Yale Exercise and Breast Cancer Survivorship Study: An Ancillary Study, 2 years, $202,000
  • Mustafa Khokha, March of Dimes, The BMP Antagonists, Noggin and Gremlin, are Required for Axial Skeleton Formation, 2 years, $150,000
  • Riku Kiviranta, International Bone & Mineral Society, The Roles of Delta FosB and MC-33, A Novel Zinc Finger Containing Protein, in Osteoblast and Adipocyte Differentiation, 2 years, $40,000
  • Anthony Koleske, American Heart Association, Regulation of Directed Cell Migration by Adhesive Cues, 5 years, $500,000
  • John Leventhal, Salomon Family Foundation, Inc., Bridging Mental Health Services for Sexually Abused Children and Their Families, 2 years, $148,162
  • Becca Levy, The Patrick and Catherine Weldon Donaghue Medical Research Foundation, Promoting Positive Age Self-Stereotypes: An Intervention, 5 years, $595,799
  • Ming Li, Arthritis Foundation, TGF-Beta Regulation of T Cell Responses in Collagen Induced Arthritis, 6 months, $75,000
  • Yilun Liu, The Milo Gladstein Foundation, Genome Instability and Tumorigenesis: The Roles of BLM and RecQ5 Helicases, 1 year, $75,000
  • Richard Matthay, Pfizer Inc., State Chest Conference, 6 months, $5,180
  • Qing Miao, American Heart Association, Role of Nogo-B Receptor in Regulating Endothelial Cell Functions, 4 years, $259,992
  • Gil Mor, Wayne State University, Services in Support of the Perinatology Research Branch, 1 year, $134,387
  • Shin Nagayama, Robert Leet and Clara Guthrie Patterson Trust, Individual Neuronal Contributions to the Function of a Cortical Network Module, 2 years, $96,000
  • Angus Nairn, Rockefeller University, Role of CK1 in Alzheimer Disease Etiology, 1 year, $49,171
  • Michael Pantalon, National Alliance for Research on Schizophrenia and Depression, Efficacy of Motivational Enhancement for Bipolar Postpartum Women, 2 years, $60,000
  • Pasko Rakic, Autism Speaks, Effect of Non-Steroidal Anti-Inflammation Drugs on Neuronal Migration, 2 years, $101,000
  • Ann Rasmusson, National Alliance for Research on Schizophrenia and Depression, Neurobiological Predictors of Response to Cognitive Processing Therapy for PTSD in Women with and without Major Depression, 2 years, $59,891
  • Michael Robek, Health Research Inc., Inhibition of Virus Replication by Lambda Interferon, 1 year, $122,868
  • Rachel Roth, PhRMA Foundation, Regulation of Energy Expenditure and Lipid Metabolism by the Mitogen Activated Protein Kinase Phosphatase-1, 2 years, $40,000
  • David Rothstein, Roche Organ Transplantation Foundation, Mechanisms of Treg Generation by Tolerogenic Agents in Transplantation, 3 years, $242,266
  • Nancy Ruddle, National Multiple Sclerosis Society, Characterization of Pathogenic Myelin Oligodendrocyte Antibodies in Multiple Sclerosis, 1 year, $44,000
  • Gary Rudnick, Autism Speaks, The N-Terminus of Serotonin Transporter—A Role in Regulation, 3 years, $82,000
  • Masanori Sasaki, Paralyzed Veterans of America, Cortical Neuronal Protection in Spinal Cord Injury Following Transplantation of BDNF-hMSCs, 2 years, $149,040
  • Srijan Sen, The Patrick and Catherine Weldon Donaghue Medical Research Foundation, Investigation into the Interaction between Genes and Stress in the Etiology of Depression in Interns, 2 years, $88,039
  • Nenad Sestan, Autism Speaks, Role of Cell Adhesion Molecule in Cortical Minicolumn, 2 years, $99,000
  • Gerald Shadel, National Organization for Hearing Research Foundation, The Role of Dual-Function Transcription Factor/rRNA Methyltransferase in Modulating Mitochondrial Translation and Susceptibility, 1 year, $20,000
  • Edward Snyder, Richard D. Frisbee III Foundation, Richard D. Frisbee III Visiting Professorship, 2 years, $6,600
  • Zhaoxia Sun, PKD Foundation for Research in Polycystic Kidney Disease, Role of Pontin in Cilia Assembly and Cyst Formation in Zebrafish, 2 years, $150,000
  • Yufeng Zhou, American Heart Association, Determine the Structural Basis of hERG Channel Blockade at Atomic Resolution, 4 months, $65,000
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Copyright 2006, Yale University School of Medicine. All rights reserved. Email comments or suggestions to: editor@info.med.yale.edu