Inside this issueCover storiesA continuous infusion of philanthropyNew Cancer Center head: ‘aspire to cure cancers’Alpern reappointed to new term as dean of medical school
PeopleLifelines: Jorge GalánExpert on spinal cord injury receives VA's highest scientific awardDean of Public Health is Anna M.R. Lauder ProfessorBerliner Professor envisions blood vessel growth as therapyExpert on kidney development, repair is named Long ProfressorFive medical school faculty are elected to a venerable groupOut & aboutScienceA protein's surprise role in Alzheimer'sHow membranes get the bendsAdvances: Living dangerously, in more ways than one | A new syndrome, a new role for a geneHealthAdvances: Relax—for your heart's sake | Drug can curb both smoking and drinkingPartnershipsGrants & contractsSupporting medical education  
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Expert on kidney development, repair is named Long ProfessorLloyd G. Cantley, M.D., professor of cellular and molecular
physiology and newly named C.N.H. Long Professor of Medicine, is a
noted nephrologist who studies the formation and repair of tubules in
the kidney, structures that are crucial to the organ’s function.
When the kidney is injured following blood loss or exposure to
toxins, the remaining epithelial cells regenerate functional tubules.
By examining epithelial cell adhesion, migration, and tubule branching
in response to growth factors, Cantley and colleagues in his laboratory
are determining the intracellular signaling events critical for tubule
formation during kidney development and following injury. Cantley also
studies the role of adult stem cells in recovery from acute tubular
necrosis, one of the most common causes of kidney failure, in which
tubule cells die. His group has found that stem cells from bone marrow
can sometimes home to injured tubules and differentiate into tubular
epithelial cells, but that their primary beneficial effect is in
secreting factors that protect existing tubular cells from death.
Members of his laboratory are presently examining how stem cells can be
mobilized for therapy in cases of acute renal failure. Cantley is associate chair for research in the Department of Internal Medicine and associate director of its nephrology fellowship program. An associate editor of the Journal of the American Society of Nephrology, Cantley has published his research in the Journal of Clinical Investigation, Molecular Cell, and Proceedings of the National Academy of Science. Cantley
earned his M.D. from the West Virginia University School of Medicine.
He completed his residency at North Carolina Memorial Hospital and his
fellowship training in nephrology at Beth Israel Hospital and Brigham
and Women’s Hospital in Boston.  |
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