Inside this issueCover storiesThree decades at the helm, and a legacyExperts on mental illness, multiple sclerosis are newest chairs
Emergency Medicine rises to independent academic department
PeopleLifelines: Fred Volkmar
Immunobiologist earns new award for top young scientistsTo honor his mother and fight melanoma, a rower shows his mettleDiabetes expert is appointed inaugural Cowgill ProfessorLeading geriatrics researcher is Humana Foundation ProfessorImmunobiologist is named Eugene Higgins Professor
Out & aboutScienceIn Yale autism research, the eyes have it
Advances: How to unleash an appetite suppressant | Genetic footprints on the trail of Lyme disease | Viruses make a move to infect new cellsHealthKeeping needs of young families in mindAdvances: Best use of flu shots? Kids and young adultsPartnershipsGrants & contracts  
Download this issue in PDF format |
|
Immunobiologist earns new award
|
|||
Susan Kaech |
The award, which includes a research grant of $1.5 million over six years, will support Kaech’s research on memory T cells, immune system cells that provide long-term protection by “remembering” pathogens that have previously caused infection.
When so-called naïve T cells encounter a new pathogen, they become activated and multiply into millions of effector T cells. These effector cells are armed with weapons that potently inhibit the replication and spread of the pathogen, or directly kill cells in the body that have already succumbed to infection. When the infection subsides, most effector T cells die, but a small number (5 to 10 percent) survive as memory T cells, providing continuing protection against reinfection by the same agent. It is this process that underlies the immunity seen after common infections such as chickenpox or that provided by most vaccines used today.
By using genetic techniques to better understand how and why this small proportion of effector cells becomes memory T cells, Kaech hopes to find ways to develop more effective vaccines.
“I feel extremely fortunate that my lab’s contributions have been recognized so highly by my colleagues,” says Kaech. “This is a very exciting time for the field, and my lab is well positioned to make significant progress in understanding the molecular mechanisms that regulate memory T cell development. This award will allow us to work faster and to pursue novel and riskier ideas that will hopefully lead to several interesting discoveries.” 
